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For instance, the mucociliary transport that oc-curs in the respiratory epithelium is one of the importantmechanisms protecting the body against invading bacteriaand other pathogens.
However, this hypothesis does not solve the question why other tumoursuppressors could not make up for the loss of p53 functions in cancer cells. The datasupport the hypothesis of an acquired dysfunction in the hepatic trans-sulfuration pathway,rather than a change in bioavailability. Indeed, an in utero exposure tomethylmercury can result in severe mental retardation andparalysis, as seen following a widespread contamination offish in Minamata Bay in Japan. Correlations have beenobserved between p53 expression and VEGF expression and micro-vessel densityin different tumour types [ 23 , 15] Correlations have beenobserved between p53 expression and VEGF expression and micro-vessel densityin different tumour types [ 23 , 15].